Reaction Details |
| Report a problem with these data |
Target | Renin |
---|
Ligand | BDBM50328867 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_673944 (CHEMBL1275121) |
---|
IC50 | 0.04±n/a nM |
---|
Citation | Corminboeuf, O; Bezençon, O; Grisostomi, C; Remen, L; Richard-Bildstein, S; Bur, D; Prade, L; Hess, P; Strickner, P; Fischli, W; Steiner, B; Treiber, A Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett20:6286-90 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Renin |
---|
Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
BDBM50328867 |
---|
n/a |
---|
Name | BDBM50328867 |
Synonyms: | CHEMBL1269698 | rac-5-chloro-4-((N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamido)methyl)-2-(3-methoxypropyl)pyridine 1-oxide |
Type | Small organic molecule |
Emp. Form. | C34H40Cl3N3O5 |
Mol. Mass. | 677.057 |
SMILES | COCCCc1cc(CN(C2CC2)C(=O)C2CNCCC2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(Cl)c[n+]1[O-] |
Structure |
|