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TargetRenin
LigandBDBM50328867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_673944 (CHEMBL1275121)
IC50 0.04±n/a nM
Citation Corminboeuf, OBezençon, OGrisostomi, CRemen, LRichard-Bildstein, SBur, DPrade, LHess, PStrickner, PFischli, WSteiner, BTreiber, A Design and optimization of new piperidines as renin inhibitors. Bioorg Med Chem Lett20:6286-90 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50328867
n/a
NameBDBM50328867
Synonyms:CHEMBL1269698 | rac-5-chloro-4-((N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)piperidine-3-carboxamido)methyl)-2-(3-methoxypropyl)pyridine 1-oxide
TypeSmall organic molecule
Emp. Form.C34H40Cl3N3O5
Mol. Mass.677.057
SMILESCOCCCc1cc(CN(C2CC2)C(=O)C2CNCCC2c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(Cl)c[n+]1[O-]
Structure
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