| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50328907 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_673988 (CHEMBL1275165) |
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| IC50 | 0.17±n/a nM |
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| Citation |  Corminboeuf, O; Bezençon, O; Remen, L; Grisostomi, C; Richard-Bildstein, S; Bur, D; Prade, L; Strickner, P; Hess, P; Fischli, W; Steiner, B; Treiber, A Piperidine-based renin inhibitors: upper chain optimization. Bioorg Med Chem Lett20:6291-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50328907 |
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| n/a |
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| Name | BDBM50328907 |
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| Synonyms: | (3R,4S)-N-(2-chloro-5-((3,3,3-trifluoropropanamido)methyl)benzyl)-N-cyclopropyl-4-(6-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)pyridin-3-yl)piperidine-3-carboxamide | CHEMBL1269745 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36Cl3F3N4O4 |
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| Mol. Mass. | 728.028 |
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| SMILES | Cc1cc(Cl)c(OCCOc2ccc(cn2)[C@H]2CCNC[C@@H]2C(=O)N(Cc2cc(CNC(=O)CC(F)(F)F)ccc2Cl)C2CC2)c(Cl)c1 |r| |
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| Structure | 
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