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TargetRenin
LigandBDBM50328865
Substrate/Competitorn/a
Meas. Tech.ChEMBL_673988 (CHEMBL1275165)
IC50 0.24±n/a nM
Citation Corminboeuf, OBezençon, ORemen, LGrisostomi, CRichard-Bildstein, SBur, DPrade, LStrickner, PHess, PFischli, WSteiner, BTreiber, A Piperidine-based renin inhibitors: upper chain optimization. Bioorg Med Chem Lett20:6291-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase | REN | RENI_HUMAN
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50328865
n/a
NameBDBM50328865
Synonyms:(3S,4R)-N-(2-chloro-5-(2-methoxyethyl)benzyl)-N-cyclopropyl-4-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)phenyl)-4-hydroxypiperidine-3-carboxamide | CHEMBL1269699
TypeSmall organic molecule
Emp. Form.C34H39Cl3N2O5
Mol. Mass.662.043
SMILESCOCCc1ccc(Cl)c(CN(C2CC2)C(=O)[C@H]2CNCC[C@]2(O)c2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c1 |r|
Structure
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