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TargetHistamine receptor (H3)
LigandBDBM50217569
Substrate/Competitorn/a
Meas. Tech.ChEMBL_673999
Ki 0.8±n/a nM
Citation Santillan AMcClure KJAllison BDLord BBoggs JDMorton KLEverson AMNepomuceno DLetavic MALee-Dutra ALovenberg TWCarruthers NIGrice CA Indole- and benzothiophene-based histamine H3 antagonists. Bioorg Med Chem Lett 20:6226-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine receptor (H3)
Name:Histamine receptor (H3 and H4)
Synonyms:G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | HRH3 | Histamine H3 Receptor | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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  Blast E-value cutoff:
BDBM50217569
n/a
NameBDBM50217569
Synonyms:4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholine | 4-[3-(4-Piperidin-1-yl-but-1-ynyl)-benzyl]-morpholine | CHEMBL237087
TypeSmall organic molecule
Emp. Form.C20H28N2O
Mol. Mass.312.4491
SMILESC(CN1CCCCC1)C#Cc1cccc(CN2CCOCC2)c1
Structure
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