Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50328975 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_674023 (CHEMBL1275200) |
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Ki | 0.69±n/a nM |
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Citation | Xiao, D; Wang, C; Palani, A; Tsui, HC; Reichard, G; Paliwal, S; Shih, NY; Aslanian, R; Duffy, R; Lachowicz, J; Varty, G; Morgan, C; Liu, F; Nomeir, A Discovery of a series of potent, orally activea,a-disubstituted piperidine NK(1) antagonists. Bioorg Med Chem Lett20:6313-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50328975 |
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n/a |
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Name | BDBM50328975 |
Synonyms: | 1-((3S,6S)-6-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-6-phenylpiperidin-3-yl)urea | CHEMBL1270272 |
Type | Small organic molecule |
Emp. Form. | C23H25F6N3O2 |
Mol. Mass. | 489.4539 |
SMILES | C[C@@H](OC[C@]1(CC[C@@H](CN1)NC(N)=O)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r| |
Structure |
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