| Reaction Details |
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 | Report a problem with these data |
| Target | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
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| Ligand | BDBM50329087 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674193 (CHEMBL1274290) |
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| IC50 | 17900±n/a nM |
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| Citation |  Li, X; Liu, N; Zhang, H; Knudson, SE; Slayden, RA; Tonge, PJ Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett20:6306-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1,4-dihydroxy-2-naphthoyl-CoA synthase |
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| Name: | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
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| Synonyms: | DHNA-CoA synthase | MENB_MYCTU | menB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 34688.06 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_817596 |
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| Residue: | 314 |
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| Sequence: | MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNA
FRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASG
DTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYAR
FKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELE
TVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFL
QKRPPDWSPFPRYF
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| BDBM50329087 |
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| n/a |
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| Name | BDBM50329087 |
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| Synonyms: | (Z)-methyl 2-(6-(ethylsulfonyl)-2-oxo-2H-benzo[b][1,4]oxazin-3(4H)-ylidene)acetate | CHEMBL1270877 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13NO6S |
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| Mol. Mass. | 311.31 |
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| SMILES | CCS(=O)(=O)c1ccc2oc(=O)c(CC(=O)OC)nc2c1 |
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| Structure | 
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