| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50329193 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674863 (CHEMBL1272436) |
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| IC50 | 61.1±n/a nM |
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| Citation |  Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors. Bioorg Med Chem18:7522-41 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 44141.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purified recombinant human 11beta-HSD2. |
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| Residue: | 405 |
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| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAV
LAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPG
AIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELS
PVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVA
LLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYI
EHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRR
RFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
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| BDBM50329193 |
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| n/a |
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| Name | BDBM50329193 |
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| Synonyms: | (3beta,18beta,20beta)-3-Acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide | CHEMBL1270688 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H49NO5 |
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| Mol. Mass. | 527.7352 |
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| SMILES | CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(=O)NO)C1(C)C |r,t:18| |
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| Structure | 
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