| Reaction Details |
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 | Report a problem with these data |
| Target | C-C motif chemokine 5 |
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| Ligand | BDBM50329238 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675123 (CHEMBL1272914) |
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| IC50 | >500±n/a nM |
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| Citation |  Wanner, J; Chen, L; Lemoine, RC; Kondru, R; Jekle, A; Heilek, G; deRosier, A; Ji, C; Berry, PW; Rotstein, DM Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series. Bioorg Med Chem Lett20:6802-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C motif chemokine 5 |
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| Name: | C-C motif chemokine 5 |
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| Synonyms: | CCL5 | CCL5_HUMAN | D17S136E | EoCP | Eosinophil chemotactic cytokine | RANTES(3-68) | RANTES(4-68) | SCYA5 | SIS-delta | Small-inducible cytokine A5 | T cell-specific protein P228 | T-cell-specific protein RANTES | TCP228 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 9996.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363187 |
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| Residue: | 91 |
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| Sequence: | MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNP
AVVFVTRKNRQVCANPEKKWVREYINSLEMS
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| BDBM50329238 |
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| n/a |
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| Name | BDBM50329238 |
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| Synonyms: | (4,6-dimethylpyrimidin-5-yl)((3aR,6aS)-5-(3-phenyl-3-(1-(2,2,2-trifluoroethyl)azetidin-3-yl)propyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)methanone | CHEMBL1271418 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34F3N5O |
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| Mol. Mass. | 501.587 |
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| SMILES | Cc1ncnc(C)c1C(=O)N1C[C@@H]2CN(CCC(C3CN(CC(F)(F)F)C3)c3ccccc3)C[C@@H]2C1 |r| |
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| Structure | 
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