| Reaction Details |
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 | Report a problem with these data |
| Target | C-C motif chemokine 5 |
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| Ligand | BDBM50329255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675123 (CHEMBL1272914) |
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| IC50 | 27±n/a nM |
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| Citation |  Wanner, J; Chen, L; Lemoine, RC; Kondru, R; Jekle, A; Heilek, G; deRosier, A; Ji, C; Berry, PW; Rotstein, DM Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series. Bioorg Med Chem Lett20:6802-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C motif chemokine 5 |
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| Name: | C-C motif chemokine 5 |
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| Synonyms: | CCL5 | CCL5_HUMAN | D17S136E | EoCP | Eosinophil chemotactic cytokine | RANTES(3-68) | RANTES(4-68) | SCYA5 | SIS-delta | Small-inducible cytokine A5 | T cell-specific protein P228 | T-cell-specific protein RANTES | TCP228 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 9996.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363187 |
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| Residue: | 91 |
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| Sequence: | MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNP
AVVFVTRKNRQVCANPEKKWVREYINSLEMS
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| BDBM50329255 |
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| n/a |
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| Name | BDBM50329255 |
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| Synonyms: | 4,6-dimethyl-5-((3aR,6aS)-5-(3-(1-(methylsulfonyl)piperidin-4-yl)-3-phenylpropyl)octahydropyrrolo[3,4-c]pyrrole-2-carbonyl)-2H-pyran-2-one | CHEMBL1271108 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H39N3O5S |
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| Mol. Mass. | 541.702 |
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| SMILES | Cc1cc(=O)oc(C)c1C(=O)N1C[C@@H]2CN(CCC(C3CCN(CC3)S(C)(=O)=O)c3ccccc3)C[C@@H]2C1 |r| |
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| Structure | 
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