Reaction Details |
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Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM50329330 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_675422 (CHEMBL1273502) |
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Ki | 870±n/a nM |
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Citation | Rai, G; Kenyon, V; Jadhav, A; Schultz, L; Armstrong, M; Jameson, JB; Hoobler, E; Leister, W; Simeonov, A; Holman, TR; Maloney, DJ Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J Med Chem53:7392-404 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1) |
Type: | Protein |
Mol. Mass.: | 74804.05 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 662 |
Sequence: | MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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BDBM50329330 |
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n/a |
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Name | BDBM50329330 |
Synonyms: | 4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)but-2-ynyl-1H-imidazole-4-carboxylate | CHEMBL1270605 |
Type | Small organic molecule |
Emp. Form. | C20H14N4O3S |
Mol. Mass. | 390.415 |
SMILES | O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1cnc[nH]1 |
Structure |
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