| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type IV |
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| Ligand | BDBM50329498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674287 (CHEMBL1274487) |
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| IC50 | >60000±n/a nM |
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| Citation |  Asano, S; Komiya, M; Koike, N; Koga, E; Nakatani, S; Isobe, Y 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett20:6696-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type IV |
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| Name: | Calcium/calmodulin-dependent protein kinase type IV |
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| Synonyms: | CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51919.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1459854 |
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| Residue: | 473 |
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| Sequence: | MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIV
YRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLEL
VTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAP
LKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEP
FYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV
TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPS
PIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKA
VEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
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| BDBM50329498 |
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| n/a |
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| Name | BDBM50329498 |
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| Synonyms: | CHEMBL1271447 | N-(6-benzyl-2-(phenethylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)naphthalene-2-sulfonamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H31N5O2S |
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| Mol. Mass. | 549.686 |
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| SMILES | O=S(=O)(Nc1nc(NCCc2ccccc2)nc2CCN(Cc3ccccc3)Cc12)c1ccc2ccccc2c1 |
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| Structure | 
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