Reaction Details |
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Target | Cathepsin D |
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Ligand | BDBM50329549 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_674724 (CHEMBL1273977) |
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IC50 | 4800±n/a nM |
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Citation | Malamas, MS; Robichaud, A; Erdei, J; Quagliato, D; Solvibile, W; Zhou, P; Morris, K; Turner, J; Wagner, E; Fan, K; Olland, A; Jacobsen, S; Reinhart, P; Riddell, D; Pangalos, M Design and synthesis of aminohydantoins as potent and selective humanß-secretase (BACE1) inhibitors with enhanced brain permeability. Bioorg Med Chem Lett20:6597-605 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin D |
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Name: | Cathepsin D |
Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
Type: | Enzyme |
Mol. Mass.: | 44551.72 |
Organism: | Homo sapiens (Human) |
Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
Residue: | 412 |
Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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BDBM50329549 |
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n/a |
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Name | BDBM50329549 |
Synonyms: | (R)-2-amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-(3-(3-methylbut-1-ynyl)phenyl)-1H-imidazol-5(4H)-one | CHEMBL1271245 |
Type | Small organic molecule |
Emp. Form. | C22H21F2N3O2 |
Mol. Mass. | 397.4178 |
SMILES | CC(C)C#Cc1cccc(c1)[C@]1(N=C(N)N(C)C1=O)c1ccc(OC(F)F)cc1 |r,t:13| |
Structure |
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