| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM50329766 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674740 (CHEMBL1273993) |
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| Kd | 70±n/a nM |
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| Citation |  Sudžius, J; Baranauskiene, L; Golovenko, D; Matuliene, J; Michailoviene, V; Torresan, J; Jachno, J; Sukackaite, R; Manakova, E; Gražulis, S; Tumkevičius, S; Matulis, D 4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII. Bioorg Med Chem18:7413-21 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase 1 |
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| Synonyms: | CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM50329766 |
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| n/a |
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| Name | BDBM50329766 |
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| Synonyms: | 4-[N-(6-Benzylamino-5-nitro-4-yl)amino]benzenesulfonamide | CHEMBL1271521 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N6O4S |
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| Mol. Mass. | 400.412 |
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| SMILES | NS(=O)(=O)c1ccc(Nc2ncnc(NCc3ccccc3)c2[N+]([O-])=O)cc1 |
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| Structure | 
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