| Reaction Details |
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 | Report a problem with these data |
| Target | TGF-beta receptor type-1 |
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| Ligand | BDBM50329814 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_674822 (CHEMBL1272395) |
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| IC50 | 15±n/a nM |
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| Citation |  Roth, GJ; Heckel, A; Brandl, T; Grauert, M; Hoerer, S; Kley, JT; Schnapp, G; Baum, P; Mennerich, D; Schnapp, A; Park, JE Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factorß receptor I (TGFßRI). J Med Chem53:7287-95 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TGF-beta receptor type-1 |
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| Name: | TGF-beta receptor type-1 |
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| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I |
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| Type: | enzyme |
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| Mol. Mass.: | 55968.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36897 |
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| Residue: | 503 |
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| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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| BDBM50329814 |
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| n/a |
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| Name | BDBM50329814 |
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| Synonyms: | (Z)-N-ethyl-3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)methylene)-2-oxoindoline-6-carboxamide | CHEMBL1272020 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N6O3 |
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| Mol. Mass. | 476.5707 |
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| SMILES | CCNC(=O)c1ccc2C(C=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)C(=O)Nc2c1 |w:10.9| |
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| Structure | 
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