| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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| Ligand | BDBM50329872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675735 (CHEMBL1272369) |
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| IC50 | 4100±n/a nM |
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| Citation |  Potter, A; Oldfield, V; Nunns, C; Fromont, C; Ray, S; Northfield, CJ; Bryant, CJ; Scrace, SF; Robinson, D; Matossova, N; Baker, L; Dokurno, P; Surgenor, AE; Davis, B; Richardson, CM; Murray, JB; Moore, JD Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution. Bioorg Med Chem Lett20:6483-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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| Name: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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| Synonyms: | PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18248.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502595 |
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| Residue: | 163 |
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| Sequence: | MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHL
LVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARG
DLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
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| BDBM50329872 |
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| n/a |
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| Name | BDBM50329872 |
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| Synonyms: | 4-((2-amino-2-oxoethyl)(methyl)carbamoyl)-2-phenyl-1H-imidazole-5-carboxylic acid | 4-[(2-amino-2-oxoethyl)(methyl)carbamoyl]-2-phenyl-1H-imidazole-5-carboxylic acid | CHEMBL1230285 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N4O4 |
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| Mol. Mass. | 302.2854 |
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| SMILES | CN(CC(N)=O)C(=O)c1nc([nH]c1C(O)=O)-c1ccccc1 |
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| Structure | 
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