| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha |
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| Ligand | BDBM50329895 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675858 (CHEMBL1272616) |
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| IC50 | 800±n/a nM |
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| Citation |  Yewalkar, N; Deore, V; Padgaonkar, A; Manohar, S; Sahu, B; Kumar, P; Jalota-Badhwar, A; Joshi, KS; Sharma, S; Kumar, S Development of novel inhibitors targeting HIF-1a towards anticancer drug discovery. Bioorg Med Chem Lett20:6426-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxia-inducible factor 1-alpha |
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| Name: | Hypoxia-inducible factor 1-alpha |
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| Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
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| Type: | Protein |
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| Mol. Mass.: | 92647.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16665 |
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| Residue: | 826 |
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| Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
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| BDBM50329895 |
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| n/a |
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| Name | BDBM50329895 |
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| Synonyms: | 2-chloro-N-(6-(4-hydroxy-6-(trifluoromethyl)pyrimidin-2-yl)pyridin-3-yl)acetamide | CHEMBL1271866 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H8ClF3N4O2 |
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| Mol. Mass. | 332.666 |
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| SMILES | FC(F)(F)c1cc(=O)[nH]c(n1)-c1ccc(NC(=O)CCl)cn1 |
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| Structure | 
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