Reaction Details |
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Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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Ligand | BDBM50330265 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_676331 (CHEMBL1273632) |
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IC50 | 231±n/a nM |
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Citation | Cho, YS; Borland, M; Brain, C; Chen, CH; Cheng, H; Chopra, R; Chung, K; Groarke, J; He, G; Hou, Y; Kim, S; Kovats, S; Lu, Y; O'Reilly, M; Shen, J; Smith, T; Trakshel, G; Vögtle, M; Xu, M; Xu, M; Sung, MJ 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem53:7938-57 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
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Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 |
Synonyms: | CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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Component 2 |
Name: | G1/S-specific cyclin-D3 |
Synonyms: | CCND3 | CCND3_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 32521.90 |
Organism: | Homo sapiens (Human) |
Description: | P30281 |
Residue: | 292 |
Sequence: | MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKML
AYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLT
IEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKK
HAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCL
RACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
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BDBM50330265 |
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n/a |
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Name | BDBM50330265 |
Synonyms: | CHEMBL1271563 | [4-(5-Bromo-3-isopropyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-(1-methyl-piperidin-4-yl)-amine |
Type | Small organic molecule |
Emp. Form. | C16H23BrN6 |
Mol. Mass. | 379.298 |
SMILES | CC(C)c1[nH]nc(Br)c1-c1ccnc(NC2CCN(C)CC2)n1 |
Structure |
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