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TargetCyclin-dependent kinase 4
LigandBDBM50330261
Substrate/Competitorn/a
Meas. Tech.ChEMBL_676335 (CHEMBL1273636)
IC50 365±n/a nM
Citation Cho, YSBorland, MBrain, CChen, CHCheng, HChopra, RChung, KGroarke, JHe, GHou, YKim, SKovats, SLu, YO'Reilly, MShen, JSmith, TTrakshel, GVögtle, MXu, MXu, MSung, MJ 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem53:7938-57 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 4
Name:Cyclin-dependent kinase 4
Synonyms:CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:Enzyme Subunit
Mol. Mass.:33731.96
Organism:Homo sapiens (Human)
Description:P11802
Residue:303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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  Blast E-value cutoff:
BDBM50330261
n/a
NameBDBM50330261
Synonyms:4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine | CHEMBL1272116
TypeSmall organic molecule
Emp. Form.C22H29ClN8
Mol. Mass.440.972
SMILESCC(C)c1n[nH]c(Cl)c1-c1ccnc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)n1
Structure
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