| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine--tRNA ligase |
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| Ligand | BDBM50330262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_676352 (CHEMBL1273653) |
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| IC50 | >10000±n/a nM |
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| Citation |  Cho, YS; Borland, M; Brain, C; Chen, CH; Cheng, H; Chopra, R; Chung, K; Groarke, J; He, G; Hou, Y; Kim, S; Kovats, S; Lu, Y; O'Reilly, M; Shen, J; Smith, T; Trakshel, G; Vögtle, M; Xu, M; Xu, M; Sung, MJ 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem53:7938-57 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine--tRNA ligase |
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| Name: | Lysine--tRNA ligase |
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| Synonyms: | KARS | KARS1 | KIAA0070 | Lysyl-tRNA synthetase | SYK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68044.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_960665 |
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| Residue: | 597 |
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| Sequence: | MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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| BDBM50330262 |
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| n/a |
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| Name | BDBM50330262 |
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| Synonyms: | CHEMBL1272171 | N*6'*-[4-(5-Isopropyl-3-trifluoromethyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-N*4*,N*4*-dimethyl-3,4,5,6-tetrahydro-2H-[1,3']-bipyridinyl-4,6'-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29F3N8 |
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| Mol. Mass. | 474.5252 |
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| SMILES | CC(C)c1[nH]nc(c1-c1ccnc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)n1)C(F)(F)F |
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| Structure | 
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