Ki Summary

Reaction Details

Report a problem with these data

Target

Beta-lactamase

Ligand

BDBM50021954

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_679490 (CHEMBL1282135)

IC50

2400±n/a nM

Citation

Dubois, V; Poirel, L; Demarthe, F; Arpin, C; Coulange, L; Minarini, LA; Bezian, MC; Nordmann, P; Quentin, C Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother52:3792-4 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Beta-lactamase SHV-11 | SHV type extended spectrum beta-lactamase

Type:

PROTEIN

Mol. Mass.:

31241.65

Organism:

Escherichia coli

Description:

ChEMBL_679490

Residue:

286

Sequence:

MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADE
RFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCA
AAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARG
IVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR

BDBM50021954

n/a

Name

BDBM50021954

Synonyms:

(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam) | CHEMBL403 | CP-45,899 | SULBACTAM | UNASYN | US20230322715, Compound ALK-09 | US9120808, Sulbactam sodium salt

Type

Small organic molecule

Emp. Form.

C8H11NO5S

Mol. Mass.

233.242

SMILES

CC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O |r|

Structure