| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Renin |
|---|
| Ligand | BDBM50330354 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_685577 (CHEMBL1285355) |
|---|
| IC50 | 0.18±n/a nM |
|---|
| Citation |  Webb, RL; Schiering, N; Sedrani, R; Maibaum, J Direct renin inhibitors as a new therapy for hypertension. J Med Chem53:7490-520 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Renin |
|---|
| Name: | Renin |
|---|
| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45058.99 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 406 |
|---|
| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
|
|
|
|---|
| BDBM50330354 |
|---|
| n/a |
|---|
| Name | BDBM50330354 |
|---|
| Synonyms: | 6-(((R)-1-(4-(3-(2-methoxybenzyloxy)propoxy)phenyl)-6-oxopiperazin-2-yl)methylthio)-4-(3-methoxypropyl)-4,4a-dihydro-2H-benzo[b][1,4]oxazin-3(8aH)-one | CHEMBL1276280 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H43N3O7S |
|---|
| Mol. Mass. | 637.786 |
|---|
| SMILES | COCCCN1C2C=C(SC[C@H]3CNCC(=O)N3c3ccc(OCCCOCc4ccccc4OC)cc3)C=CC2OCC1=O |r,c:41,t:7| |
|---|
| Structure | 
|
|---|
Search and Browse
