| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM50330391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_684503 (CHEMBL1287512) |
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| Ki | 1.1±n/a nM |
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| Citation |  Cui, H; Ruda, GF; Carrero-Lérida, J; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem45:5140-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Purine Nucleoside Phosphorylase (PNP) | pfPNP |
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| Type: | Enzyme |
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| Mol. Mass.: | 26857.85 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 245 |
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| Sequence: | MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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| BDBM50330391 |
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| n/a |
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| Name | BDBM50330391 |
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| Synonyms: | 5-(3-(benzyloxy)benzyl)-1-((2-hydroxyethoxy)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione | CHEMBL1277898 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N2O6 |
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| Mol. Mass. | 398.4092 |
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| SMILES | OCCOCn1c(O)c(Cc2cccc(OCc3ccccc3)c2)c(=O)[nH]c1=O |
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| Structure | 
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