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TargetPurine Nucleoside Phosphorylase (PNP)
LigandBDBM50330391
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684503
Ki 1.1±n/a nM
Citation Cui HRuda GFCarrero-Lérida JRuiz-Pérez LMGilbert IHGonzález-Pacanowska D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article
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Purine Nucleoside Phosphorylase (PNP)
Name:Purine Nucleoside Phosphorylase (PNP)
Synonyms:pfPNP
Type:Enzyme
Mol. Mass.:26857.85
Organism:Plasmodium falciparum
Description:n/a
Residue:245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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BDBM50330391
n/a
NameBDBM50330391
Synonyms:5-(3-(benzyloxy)benzyl)-1-((2-hydroxyethoxy)methyl)pyrimidine-2,4,6(1H,3H,5H)-trione | CHEMBL1277898
TypeSmall organic molecule
Emp. Form.C21H22N2O6
Mol. Mass.398.4092
SMILESOCCOCn1c(O)c(Cc2cccc(OCc3ccccc3)c2)c(=O)[nH]c1=O
Structure
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