Reaction Details |
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Target | Aldo-keto reductase family 1 member C1 |
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Ligand | BDBM50330432 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_684679 (CHEMBL1285646) |
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Ki | 2±n/a nM |
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Citation | El-Kabbani, O; Scammells, PJ; Day, T; Dhagat, U; Endo, S; Matsunaga, T; Soda, M; Hara, A Structure-based optimization and biological evaluation of human 20a-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors. Eur J Med Chem45:5309-17 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member C1 |
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Name: | Aldo-keto reductase family 1 member C1 |
Synonyms: | 20-alpha-HSD | 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) | AK1C1_HUMAN | AKR1C1 | Aldo-keto reductase family 1 member C1 (AK1C1) | Aldo-keto reductase family 1 member C1 (AK1C1a) | Aldo-keto reductase family 1 member C1 (AKR1C1) | Chlordecone reductase homolog HAKRC | DDH | DDH1 | High-affinity hepatic bile acid-binding protein | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 36793.97 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant AKR1C1 enzyme was expressed in E. coli. |
Residue: | 323 |
Sequence: | MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPV
SVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKP
GLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPV
LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLN
RNVRYLTLDIFAGPPNYPFSDEY
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BDBM50330432 |
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n/a |
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Name | BDBM50330432 |
Synonyms: | 5-Chloro-4-hydroxy-4'-isobutylbiphenyl-3-carboxylic acid | CHEMBL1277648 |
Type | Small organic molecule |
Emp. Form. | C17H17ClO3 |
Mol. Mass. | 304.768 |
SMILES | CC(C)Cc1ccc(cc1)-c1cc(Cl)c(O)c(c1)C(O)=O |
Structure |
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