| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 |
|---|
| Ligand | BDBM50330578 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_685029 (CHEMBL1286645) |
|---|
| IC50 | 410±n/a nM |
|---|
| Citation |  Whelligan, DK; Solanki, S; Taylor, D; Thomson, DW; Cheung, KM; Boxall, K; Mas-Droux, C; Barillari, C; Burns, S; Grummitt, CG; Collins, I; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem53:7682-98 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Nek2 |
|---|
| Name: | Serine/threonine-protein kinase Nek2 |
|---|
| Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51776.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51955 |
|---|
| Residue: | 445 |
|---|
| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
|
|
|
|---|
| BDBM50330578 |
|---|
| n/a |
|---|
| Name | BDBM50330578 |
|---|
| Synonyms: | 1-(3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acid | 1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid | CHEMBL1231522 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H24N4O5 |
|---|
| Mol. Mass. | 388.4177 |
|---|
| SMILES | COc1cc(cc(OC)c1OC)-c1cnc(N)c(n1)N1CCC(CC1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
