| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 |
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| Ligand | BDBM50330575 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_685030 (CHEMBL1286646) |
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| IC50 | 200±n/a nM |
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| Citation |  Whelligan, DK; Solanki, S; Taylor, D; Thomson, DW; Cheung, KM; Boxall, K; Mas-Droux, C; Barillari, C; Burns, S; Grummitt, CG; Collins, I; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J Med Chem53:7682-98 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek2 |
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| Name: | Serine/threonine-protein kinase Nek2 |
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| Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51776.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51955 |
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| Residue: | 445 |
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| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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| BDBM50330575 |
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| n/a |
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| Name | BDBM50330575 |
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| Synonyms: | (-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)-2,3-dimethylpiperidine-4-carboxylic Acid | CHEMBL1276848 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N4O5 |
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| Mol. Mass. | 416.4708 |
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| SMILES | COc1cc(cc(OC)c1OC)-c1cnc(N)c(n1)N1CC[C@H]([C@@H](C)[C@H]1C)C(O)=O |r| |
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| Structure | 
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