Reaction Details |
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Target | NADPH oxidase 4 |
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Ligand | BDBM50330718 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_685143 (CHEMBL1286959) |
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Ki | 158±n/a nM |
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Citation | Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NADPH oxidase 4 |
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Name: | NADPH oxidase 4 |
Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase |
Type: | PROTEIN |
Mol. Mass.: | 66954.54 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_792879 |
Residue: | 578 |
Sequence: | MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRAS
ASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHV
AAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTY
AIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLP
EYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLY
RYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCP
TETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEES
LNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLH
NKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGK
TVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
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BDBM50330718 |
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n/a |
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Name | BDBM50330718 |
Synonyms: | 2-(2-chlorophenyl)-4-methyl-5-(3-phenylprop-2-ynyl)-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1278200 |
Type | Small organic molecule |
Emp. Form. | C22H16ClN3O2 |
Mol. Mass. | 389.834 |
SMILES | Cc1n(CC#Cc2ccccc2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12 |
Structure |
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