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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | NADPH oxidase 4 | ||
| Ligand | BDBM50330746 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685143 (CHEMBL1286959) | ||
| Ki | 128±n/a nM | ||
| Citation |  Laleu, B; Gaggini, F; Orchard, M; Fioraso-Cartier, L; Cagnon, L; Houngninou-Molango, S; Gradia, A; Duboux, G; Merlot, C; Heitz, F; Szyndralewiez, C; Page, P First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem53:7715-30 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| NADPH oxidase 4 | |||
| Name: | NADPH oxidase 4 | ||
| Synonyms: | KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NOX4 | NOX4_HUMAN | RENOX | Renal NAD(P)H-oxidase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 66954.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_792879 | ||
| Residue: | 578 | ||
| Sequence: |
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| BDBM50330746 | |||
| n/a | |||
| Name | BDBM50330746 | ||
| Synonyms: | 2-(2-chlorophenyl)-4-(2-fluorophenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione | CHEMBL1278018 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H13ClFN3O2 | ||
| Mol. Mass. | 369.777 | ||
| SMILES | Cn1c(-c2ccccc2F)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O |(55.19,-34.39,;53.86,-35.16,;52.52,-34.4,;52.52,-32.86,;51.18,-32.11,;51.17,-30.57,;52.5,-29.78,;53.84,-30.55,;53.85,-32.09,;55.18,-32.86,;51.19,-35.17,;51.19,-36.71,;52.53,-37.49,;53.87,-36.71,;55.2,-37.48,;49.73,-37.19,;48.82,-35.94,;47.28,-35.94,;46.52,-37.27,;44.98,-37.28,;44.21,-35.94,;44.98,-34.6,;46.52,-34.6,;47.3,-33.27,;49.73,-34.7,;49.26,-33.23,)| | ||
| Structure | 
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