| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H1 receptor |
|---|
| Ligand | BDBM50330747 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_685211 |
|---|
| Ki | 4.68±n/a nM |
|---|
| Citation |  Gianotti M; Botta M; Brough S; Carletti R; Castiglioni E; Corti C; Dal-Cin M; Delle Fratte S; Korajac D; Lovric M; Merlo G; Mesic M; Pavone F; Piccoli L; Rast S; Roscic M; Sava A; Smehil M; Stasi L; Togninelli A; Wigglesworth MJ Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders. J Med Chem 53:7778-95 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H1 receptor |
|---|
| Name: | Histamine H1 receptor |
|---|
| Synonyms: | HISTAMINE H1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 55716.35 |
|---|
| Organism: | RAT |
|---|
| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
|
|
|
|---|
| BDBM50330747 |
|---|
| n/a |
|---|
| Name | BDBM50330747 |
|---|
| Synonyms: | (-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo-[a,d]cyclohepten]-3-yl)-4-piperidinecarboxylic Acid | CHEMBL1277770 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H29NO2 |
|---|
| Mol. Mass. | 375.5033 |
|---|
| SMILES | OC(=O)C1CCN(CC1)C1CC[C@@]2(C1)Cc1ccccc1Cc1ccccc21 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
