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TargetHistamine H1 receptor
LigandBDBM50330747
Substrate/Competitorn/a
Meas. Tech.ChEMBL_685211
Ki 4.68±n/a nM
Citation Gianotti MBotta MBrough SCarletti RCastiglioni ECorti CDal-Cin MDelle Fratte SKorajac DLovric MMerlo GMesic MPavone FPiccoli LRast SRoscic MSava ASmehil MStasi LTogninelli AWigglesworth MJ Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders. J Med Chem 53:7778-95 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:HISTAMINE H1
Type:Enzyme Catalytic Domain
Mol. Mass.:55716.35
Organism:RAT
Description:HISTAMINE H1 HRH1 RAT::P31390
Residue:486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
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  Blast E-value cutoff:
BDBM50330747
n/a
NameBDBM50330747
Synonyms:(-)-1-((1S)-5',11'-Dihydrospiro[cyclopentane-1,10'-dibenzo-[a,d]cyclohepten]-3-yl)-4-piperidinecarboxylic Acid | CHEMBL1277770
TypeSmall organic molecule
Emp. Form.C25H29NO2
Mol. Mass.375.5033
SMILESOC(=O)C1CCN(CC1)C1CC[C@@]2(C1)Cc1ccccc1Cc1ccccc21 |r|
Structure
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