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TargetHistamine H1 receptor
LigandBDBM50417376
Substrate/Competitorn/a
Meas. Tech.ChEMBL_685205 (CHEMBL1287093)
Ki 3.98±n/a nM
Citation Gianotti, MBotta, MBrough, SCarletti, RCastiglioni, ECorti, CDal-Cin, MDelle Fratte, SKorajac, DLovric, MMerlo, GMesic, MPavone, FPiccoli, LRast, SRoscic, MSava, ASmehil, MStasi, LTogninelli, AWigglesworth, MJ Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders. J Med Chem53:7778-95 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:55808.72
Organism:Homo sapiens (Human)
Description:Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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  Blast E-value cutoff:
BDBM50417376
n/a
NameBDBM50417376
Synonyms:CHEMBL1278116
TypeSmall organic molecule
Emp. Form.C21H25N
Mol. Mass.291.4299
SMILESCN(C)C1CC[C@@]2(C1)Cc1ccccc1Cc1ccccc21 |r|
Structure
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