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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50026207 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685663 (CHEMBL1285565) | ||
| IC50 | <0.100000±n/a nM | ||
| Citation |  Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50026207 | |||
| n/a | |||
| Name | BDBM50026207 | ||
| Synonyms: | CHEMBL1276170 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H25ClN8 | ||
| Mol. Mass. | 533.026 | ||
| SMILES | [H][C@]12CN(c3ccc(c(Cl)c3)-c3ccnc4c(c(nn34)-c3ccncc3)-c3cccc4[nH]ncc34)[C@]([H])(CN1C)C2 |r,wU:35.41,1.0,(38.98,4.96,;37.9,3.86,;37.9,2.32,;36.57,1.54,;36.58,.01,;37.92,-.76,;37.92,-2.3,;36.58,-3.07,;35.25,-2.31,;33.92,-3.09,;35.24,-.77,;36.59,-4.61,;35.26,-5.38,;35.26,-6.93,;36.6,-7.7,;37.93,-6.92,;39.41,-7.4,;40.32,-6.15,;39.41,-4.89,;37.93,-5.37,;41.86,-6.14,;42.63,-7.48,;44.17,-7.48,;44.94,-6.15,;44.16,-4.81,;42.62,-4.81,;39.88,-8.87,;41.39,-9.18,;41.87,-10.64,;40.83,-11.8,;39.32,-11.48,;38.08,-12.37,;36.84,-11.46,;37.32,-10.01,;38.86,-10.01,;35.24,2.3,;33.69,2.3,;35.22,3.84,;36.56,4.62,;36.55,6.17,;36.32,3.4,)| | ||
| Structure | 
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