Reaction Details | |||
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Target | Serine/threonine-protein kinase B-raf | ||
Ligand | BDBM50330917 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_685663 (CHEMBL1285565) | ||
IC50 | 0.610000±n/a nM | ||
Citation | Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase B-raf | |||
Name: | Serine/threonine-protein kinase B-raf | ||
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 84446.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P15056 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50330917 | |||
n/a | |||
Name | BDBM50330917 | ||
Synonyms: | 7-(2,3-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | CHEMBL1276177 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H24F2N8 | ||
Mol. Mass. | 534.562 | ||
SMILES | CN1C[C@@H]2C[C@H]1CN2c1ccc(c(F)c1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |r,wU:3.3,5.4,(1.07,-33.28,;1.07,-34.82,;-.26,-35.61,;-.25,-37.15,;.83,-36.05,;2.41,-35.59,;2.42,-37.13,;1.08,-37.91,;1.09,-39.44,;2.43,-40.21,;2.44,-41.75,;1.1,-42.52,;-.23,-41.76,;-1.56,-42.54,;-.24,-40.22,;-1.58,-39.46,;1.11,-44.06,;-.22,-44.83,;-.22,-46.37,;1.11,-47.14,;2.45,-46.37,;3.92,-46.85,;4.83,-45.6,;3.92,-44.34,;2.45,-44.82,;6.37,-45.59,;7.14,-46.93,;8.68,-46.93,;9.45,-45.59,;8.67,-44.25,;7.14,-44.26,;4.4,-48.31,;5.9,-48.63,;6.38,-50.09,;5.35,-51.25,;3.84,-50.92,;2.59,-51.82,;1.35,-50.91,;1.84,-49.45,;3.37,-49.46,)| | ||
Structure |