Reaction Details | |||
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Target | Serine/threonine-protein kinase B-raf | ||
Ligand | BDBM50330919 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_685663 (CHEMBL1285565) | ||
IC50 | 0.510000±n/a nM | ||
Citation | Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase B-raf | |||
Name: | Serine/threonine-protein kinase B-raf | ||
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 84446.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P15056 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50330919 | |||
n/a | |||
Name | BDBM50330919 | ||
Synonyms: | 3-(1H-indazol-4-yl)-7-(2-methyl-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | CHEMBL1276168 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H28N8 | ||
Mol. Mass. | 512.6076 | ||
SMILES | CN1C[C@@H]2C[C@H]1CN2c1ccc(c(C)c1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |r,wU:3.3,5.4,(14.11,6.43,;14.12,4.89,;12.79,4.1,;12.8,2.57,;13.88,3.67,;15.46,4.12,;15.47,2.58,;14.13,1.81,;14.14,.27,;15.48,-.49,;15.48,-2.03,;14.15,-2.81,;12.81,-2.05,;11.48,-2.82,;12.8,-.51,;14.16,-4.34,;12.83,-5.11,;12.83,-6.66,;14.16,-7.43,;15.49,-6.66,;16.97,-7.14,;17.88,-5.88,;16.97,-4.63,;15.49,-5.11,;19.42,-5.88,;20.19,-7.22,;21.73,-7.22,;22.5,-5.88,;21.72,-4.54,;20.18,-4.55,;17.45,-8.6,;18.95,-8.92,;19.43,-10.38,;18.4,-11.53,;16.89,-11.21,;15.64,-12.11,;14.4,-11.2,;14.88,-9.74,;16.42,-9.75,)| | ||
Structure |