Reaction Details | |||
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Target | Serine/threonine-protein kinase B-raf | ||
Ligand | BDBM50330920 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_685663 (CHEMBL1285565) | ||
IC50 | 0.500000±n/a nM | ||
Citation | Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase B-raf | |||
Name: | Serine/threonine-protein kinase B-raf | ||
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 84446.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P15056 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50330920 | |||
n/a | |||
Name | BDBM50330920 | ||
Synonyms: | 3-(7-fluoro-1H-indazol-4-yl)-7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | CHEMBL1276183 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H25FN8 | ||
Mol. Mass. | 516.5715 | ||
SMILES | CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1ccc(F)c2[nH]ncc12 |r,wU:3.3,5.4,(28.5,5.92,;28.51,4.38,;27.17,3.6,;27.18,2.06,;28.27,3.16,;29.85,3.62,;29.85,2.08,;28.52,1.3,;28.53,-.23,;29.86,-1,;29.87,-2.54,;28.53,-3.31,;27.2,-2.55,;27.19,-1.01,;28.54,-4.85,;27.21,-5.62,;27.21,-7.17,;28.55,-7.94,;29.88,-7.16,;31.36,-7.64,;32.27,-6.39,;31.35,-5.13,;29.88,-5.61,;33.8,-6.38,;34.57,-7.72,;36.11,-7.72,;36.89,-6.39,;36.11,-5.05,;34.57,-5.05,;31.83,-9.11,;33.33,-9.42,;33.81,-10.88,;32.78,-12.04,;33.26,-13.5,;31.27,-11.72,;30.03,-12.61,;28.79,-11.71,;29.27,-10.25,;30.8,-10.25,)| | ||
Structure |