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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50330922 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685663 (CHEMBL1285565) | ||
| IC50 | 0.380000±n/a nM | ||
| Citation |  Wang, X; Berger, DM; Salaski, EJ; Torres, N; Dutia, M; Hanna, C; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E; Lucas, J Indazolylpyrazolopyrimidine as highly potent B-Raf inhibitors with in vivo activity. J Med Chem53:7874-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50330922 | |||
| n/a | |||
| Name | BDBM50330922 | ||
| Synonyms: | 7-(2,5-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-3-(1H-indazol-4-yl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine | CHEMBL1276178 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H24F2N8 | ||
| Mol. Mass. | 534.562 | ||
| SMILES | CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(cc1F)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc2[nH]ncc12 |r,wU:3.3,5.4,(12.11,-32.8,;12.12,-34.34,;10.78,-35.12,;10.8,-36.66,;11.88,-35.56,;13.46,-35.1,;13.47,-36.64,;12.13,-37.42,;12.14,-38.95,;10.8,-39.73,;10.81,-41.27,;9.48,-42.05,;12.15,-42.03,;13.48,-41.26,;13.48,-39.72,;14.81,-38.95,;12.16,-43.57,;10.83,-44.34,;10.82,-45.89,;12.16,-46.66,;13.49,-45.88,;14.97,-46.36,;15.88,-45.11,;14.97,-43.85,;13.49,-44.33,;17.42,-45.1,;18.19,-46.44,;19.73,-46.44,;20.5,-45.11,;19.72,-43.77,;18.18,-43.77,;15.44,-47.83,;16.95,-48.14,;17.43,-49.6,;16.39,-50.76,;14.88,-50.44,;13.64,-51.33,;12.4,-50.42,;12.88,-48.97,;14.42,-48.97,)| | ||
| Structure | 
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