| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Ligand | BDBM50330999 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_684635 (CHEMBL1285468) |
|---|
| IC50 | 8±n/a nM |
|---|
| Citation |  Oster, A; Hinsberger, S; Werth, R; Marchais-Oberwinkler, S; Frotscher, M; Hartmann, RW Bicyclic substituted hydroxyphenylmethanones as novel inhibitors of 17ß-hydroxysteroid dehydrogenase type 1 (17ß-HSD1) for the treatment of estrogen-dependent diseases. J Med Chem53:8176-86 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Name: | 17-beta-hydroxysteroid dehydrogenase type 1 |
|---|
| Synonyms: | 17-beta-HSD 1 | 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB1_HUMAN | E17KSR | E2DH | EDH17B1 | EDH17B2 | EDHB17 | Estradiol 17-beta-dehydrogenase 1 | Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1) | HSD17B1 | Placental 17-beta-hydroxysteroid dehydrogenase | SDR28C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 34945.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14061 |
|---|
| Residue: | 328 |
|---|
| Sequence: | MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
|
|
|
|---|
| BDBM50330999 |
|---|
| n/a |
|---|
| Name | BDBM50330999 |
|---|
| Synonyms: | CHEMBL1277708 | [5-(4-Hydroxy-3-methylphenyl)-2-thienyl](3-hydroxyphenyl)-methanone |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14O3S |
|---|
| Mol. Mass. | 310.367 |
|---|
| SMILES | Cc1cc(ccc1O)-c1ccc(s1)C(=O)c1cccc(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
