| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50331300 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_686645 (CHEMBL1292498) |
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| Ki | >1000±n/a nM |
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| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50331300 |
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| n/a |
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| Name | BDBM50331300 |
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| Synonyms: | (+/-)-7-(Benzyloxy)-3-{3-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]propyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol | CHEMBL1290496 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38FNO4 |
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| Mol. Mass. | 519.6468 |
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| SMILES | CC1(C)COC(CCCN2CCc3cc(OCc4ccccc4)ccc3C(O)C2)(OC1)c1ccc(F)cc1 |
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| Structure | 
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