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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50331304 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_686645 (CHEMBL1292498) | ||
| Ki | 186±n/a nM | ||
| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein | ||
| Type: | Protein | ||
| Mol. Mass.: | 25307.17 | ||
| Organism: | Cavia porcellus (Guinea pig) | ||
| Description: | Q60492 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50331304 | |||
| n/a | |||
| Name | BDBM50331304 | ||
| Synonyms: | CHEMBL1290725 | rac-7-Benzyloxy-3-(2-phenyl-1,3-dioxan-5-yl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H29NO4 | ||
| Mol. Mass. | 431.5235 | ||
| SMILES | OC1CN(CCc2cc(OCc3ccccc3)ccc12)C1COC(OC1)c1ccccc1 |(-.41,-42.15,;-.02,-43.6,;1.5,-43.85,;2.27,-45.28,;1.61,-46.73,;.09,-47.1,;-1.21,-46.09,;-2.51,-46.84,;-3.81,-46.08,;-5.11,-46.84,;-6.41,-46.09,;-7.71,-46.85,;-9.01,-46.11,;-10.31,-46.86,;-10.31,-48.36,;-9.01,-49.11,;-7.7,-48.36,;-3.82,-44.59,;-2.53,-43.83,;-1.22,-44.58,;3.89,-45.22,;4.75,-46.6,;6.36,-46.55,;7.13,-45.12,;6.27,-43.73,;4.64,-43.78,;8.75,-45.07,;9.6,-46.45,;11.22,-46.41,;11.99,-44.98,;11.13,-43.59,;9.51,-43.65,)| | ||
| Structure | 
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