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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sigma non-opioid intracellular receptor 1 | ||
| Ligand | BDBM50331316 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_686645 (CHEMBL1292498) | ||
| Ki | >1000±n/a nM | ||
| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sigma non-opioid intracellular receptor 1 | |||
| Name: | Sigma non-opioid intracellular receptor 1 | ||
| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein | ||
| Type: | Protein | ||
| Mol. Mass.: | 25307.17 | ||
| Organism: | Cavia porcellus (Guinea pig) | ||
| Description: | Q60492 | ||
| Residue: | 223 | ||
| Sequence: |
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| BDBM50331316 | |||
| n/a | |||
| Name | BDBM50331316 | ||
| Synonyms: | (+/-)-trans-3-(2-Phenyl-1,3-dioxan-5-yl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol | CHEMBL1289733 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23NO4 | ||
| Mol. Mass. | 341.4009 | ||
| SMILES | OC1CN(CCc2cc(O)ccc12)[C@H]1CO[C@@H](OC1)c1ccccc1 |r,wU:16.21,wD:13.14,(30.75,-3.37,;31.13,-4.81,;32.64,-5.06,;33.4,-6.48,;32.76,-7.92,;31.24,-8.29,;29.96,-7.28,;28.66,-8.03,;27.36,-7.28,;26.08,-8.03,;27.36,-5.8,;28.64,-5.05,;29.94,-5.78,;35.01,-6.48,;35.82,-7.87,;37.42,-7.87,;38.23,-6.49,;37.42,-5.09,;35.81,-5.09,;39.76,-6.49,;40.53,-7.83,;42.07,-7.84,;42.85,-6.5,;42.07,-5.16,;40.53,-5.16,)| | ||
| Structure | 
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