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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 1/2B | ||
| Ligand | BDBM50331307 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_686641 (CHEMBL1292494) | ||
| Ki | 388±n/a nM | ||
| Citation |  Tewes, B; Frehland, B; Schepmann, D; Schmidtke, KU; Winckler, T; Wünsch, B Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorg Med Chem18:8005-15 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 1/2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 1/2B | ||
| Synonyms: | GluN1/GluN2B NMDA receptor | Glutamate NMDA receptor; GRIN1/GRIN2B | Glutamate [NMDA] receptor subunit epsilon 2/zeta 1 | NR1/NR2B | nr2b nam | ||
| Type: | Enzyme | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Glutamate receptor ionotropic, NMDA 1 | ||
| Synonyms: | GRIN1 | Glutamate (NMDA) receptor subunit zeta 1 | Glutamate [NMDA] receptor subunit zeta-1 | Ionotropic glutamate receptor NMDA 1/2D | N-methyl-D-aspartate receptor subunit NR1 | NMDAR1 | NMDZ1_HUMAN | phencyclidine | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 105397.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q05586 | ||
| Residue: | 938 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GRIN2B | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Glutamate [NMDA] receptor subunit epsilon-2 | N-methyl D-aspartate receptor subtype 2B | N-methyl-D-aspartate receptor subunit 3 | NMDAR2B | NMDE2_HUMAN | NR3 | hNR3 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 166375.46 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1438829 | ||
| Residue: | 1484 | ||
| Sequence: |
| ||
| BDBM50331307 | |||
| n/a | |||
| Name | BDBM50331307 | ||
| Synonyms: | CHEMBL1289058 | trans-7-(Benzyloxy)-3-(4-phenylcyclohexyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H33NO2 | ||
| Mol. Mass. | 427.5778 | ||
| SMILES | OC1CN(CCc2cc(OCc3ccccc3)ccc12)[C@H]1CC[C@@H](CC1)c1ccccc1 |r,wU:23.29,wD:20.22,(25.44,6.92,;25.82,5.49,;27.33,5.24,;28.09,3.82,;27.44,2.39,;25.93,2.03,;24.66,3.02,;23.36,2.28,;22.08,3.02,;20.8,2.28,;19.51,3.02,;18.23,2.27,;16.94,3.01,;15.66,2.26,;15.66,.78,;16.94,.03,;18.24,.78,;22.07,4.5,;23.34,5.25,;24.65,4.52,;29.69,3.83,;30.49,2.44,;32.1,2.44,;32.9,3.82,;32.1,5.22,;30.48,5.22,;34.5,3.82,;35.29,2.43,;36.9,2.43,;37.7,3.81,;36.89,5.21,;35.29,5.2,)| | ||
| Structure | 
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