Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50331365 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687130 (CHEMBL1291707) |
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IC50 | 1.2±n/a nM |
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Citation | Yan, X; Wang, Z; Sudom, A; Cardozo, M; DeGraffenreid, M; Di, Y; Fan, P; He, X; Jaen, JC; Labelle, M; Liu, J; Ma, J; McMinn, D; Miao, S; Sun, D; Tang, L; Tu, H; Ursu, S; Walker, N; Ye, Q; Powers, JP The synthesis and SAR of novel diarylsulfone 11ß-HSD1 inhibitors. Bioorg Med Chem Lett20:7071-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50331365 |
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n/a |
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Name | BDBM50331365 |
Synonyms: | (S)-3'-(2-fluoroethyl)-4'-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)biphenyl-4-carbonitrile | CHEMBL1289629 |
Type | Small organic molecule |
Emp. Form. | C24H19F4NO3S |
Mol. Mass. | 477.471 |
SMILES | C[C@](O)(c1ccc(cc1)S(=O)(=O)c1ccc(cc1CCF)-c1ccc(cc1)C#N)C(F)(F)F |r| |
Structure |
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