| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50331549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_687309 (CHEMBL1291985) |
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| Ki | 230±n/a nM |
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| Citation |  Höfling, SB; Maschauer, S; Hübner, H; Gmeiner, P; Wester, HJ; Prante, O; Heinrich, MR Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET. Bioorg Med Chem Lett20:6933-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HT-2 | 5-HT-2A | 5-HT2 | 5-HT2A | 5HT2A_PIG | HTR2A | Serotonin 2a (5-HT2a) receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52679.13 |
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| Organism: | PIG |
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| Description: | 5-HT2 0 0::P50129 |
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| Residue: | 470 |
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| Sequence: | MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGAL
LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS
SQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
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| BDBM50331549 |
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| n/a |
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| Name | BDBM50331549 |
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| Synonyms: | CHEMBL567286 | [11C]-3-(2-oxo-3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)imidazolidin-1-yl)benzonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21F3N4O |
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| Mol. Mass. | 366.3807 |
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| SMILES | FC(F)(F)C1CCN(CCN2CCN(C2=O)c2cccc(c2)C#N)CC1 |
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| Structure | 
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