Reaction Details |
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Target | Cathepsin L2 |
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Ligand | BDBM50331556 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687420 (CHEMBL1292096) |
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IC50 | 36.3±n/a nM |
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Citation | Cai, J; Robinson, J; Belshaw, S; Everett, K; Fradera, X; van Zeeland, M; van Berkom, L; van Rijnsbergen, P; Popplestone, L; Baugh, M; Dempster, M; Bruin, J; Hamilton, W; Kinghorn, E; Westwood, P; Kerr, J; Rankovic, Z; Arbuckle, W; Bennett, DJ; Jones, PS; Long, C; Martin, I; Uitdehaag, JC; Meulemans, T Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors. Bioorg Med Chem Lett20:6890-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin L2 |
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Name: | Cathepsin L2 |
Synonyms: | CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V |
Type: | Enzyme |
Mol. Mass.: | 37341.06 |
Organism: | Homo sapiens (Human) |
Description: | O60911 |
Residue: | 334 |
Sequence: | MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
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BDBM50331556 |
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n/a |
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Name | BDBM50331556 |
Synonyms: | 2-chloro-N-(4-(1-methyl-1H-pyrazol-3-ylamino)-3,4-dioxobutan-2-yl)-4-(pyridin-2-ylmethoxy)-3-(trifluoromethyl)benzamide | CHEMBL1289644 |
Type | Small organic molecule |
Emp. Form. | C22H19ClF3N5O4 |
Mol. Mass. | 509.866 |
SMILES | CC(NC(=O)c1ccc(OCc2ccccn2)c(c1Cl)C(F)(F)F)C(=O)C(=O)Nc1ccn(C)n1 |
Structure |
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