Reaction Details |
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Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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Ligand | BDBM50331612 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687462 (CHEMBL1292138) |
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IC50 | 129000±n/a nM |
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Citation | Krug, M; Erlenkamp, G; Sippl, W; Schächtele, C; Totzke, F; Hilgeroth, A Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett20:6915-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
Synonyms: | CDK6/cyclin D1 | Cyclin-dependent kinase 6/G1/S-specific cyclin D1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1935149 |
Components: | This complex has 2 components. |
Component 1 |
Name: | G1/S-specific cyclin-D1 |
Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene |
Type: | Enzyme Subunit |
Mol. Mass.: | 33717.70 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 295 |
Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
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Component 2 |
Name: | Cyclin-dependent kinase 6 |
Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
Type: | Enzyme Subunit |
Mol. Mass.: | 36937.42 |
Organism: | Homo sapiens (Human) |
Description: | Q00534 |
Residue: | 326 |
Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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BDBM50331612 |
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n/a |
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Name | BDBM50331612 |
Synonyms: | CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine |
Type | Small organic molecule |
Emp. Form. | C19H16N2O2 |
Mol. Mass. | 304.3425 |
SMILES | COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1 |
Structure |
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