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TargetVitamin K-dependent protein C
LigandBDBM50331666
Substrate/Competitorn/a
Meas. Tech.ChEMBL_687653 (CHEMBL1290977)
IC50 103500±n/a nM
Citation Hanessian, SLarsson, AFex, TKnecht, WBlomberg, N Design and synthesis of macrocyclic indoles targeting blood coagulation cascade Factor XIa. Bioorg Med Chem Lett20:6925-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Vitamin K-dependent protein C
Name:Vitamin K-dependent protein C
Synonyms:Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor
Type:Enzyme
Mol. Mass.:52067.73
Organism:Homo sapiens (Human)
Description:n/a
Residue:461
Sequence:
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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  Blast E-value cutoff:
BDBM50331666
n/a
NameBDBM50331666
Synonyms:(S)-N-((R)-2-((S)-1-((2-allyl-5-chloro-1H-indol-3-yl)methylamino)-4-methyl-1-oxopentan-2-ylamino)-1-cyclohexyl-2-oxoethyl)-2-phenylpent-4-enamide | CHEMBL1288925
TypeSmall organic molecule
Emp. Form.C37H47ClN4O3
Mol. Mass.631.247
SMILESCC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@@H](CC=C)c1ccccc1)C1CCCCC1)C(=O)NCc1c(CC=C)[nH]c2ccc(Cl)cc12 |r|
Structure
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