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TargetC-C chemokine receptor type 2
LigandBDBM50331727
Substrate/Competitorn/a
Meas. Tech.ChEMBL_687876 (CHEMBL1291440)
IC50 2.1±n/a nM
Citation Xue, CBWang, AMeloni, DZhang, KKong, LFeng, HGlenn, JHuang, TZhang, YCao, GAnand, RZheng, CXia, MHan, QRobinson, DJStorace, LShao, LLi, MBrodmerkel, CMCovington, MScherle, PDiamond, SYeleswaram, SVaddi, KNewton, RHollis, GFriedman, SMetcalf, B Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2. Bioorg Med Chem Lett20:7473-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:CCR2_MOUSE | Ccr2 | Cmkbr2
Type:PROTEIN
Mol. Mass.:42795.68
Organism:Mus musculus
Description:ChEMBL_1502265
Residue:373
Sequence:
MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPP
LYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWV
FGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVV
AVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILH
TLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAM
QVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTF
TPSTGEQEVSVGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50331727
n/a
NameBDBM50331727
Synonyms:CHEMBL1289203 | N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
TypeSmall organic molecule
Emp. Form.C29H36F3N3O4
Mol. Mass.547.609
SMILESCCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc(C)cc1 |r,wU:3.2,25.26,wD:7.8,28.30,(4.62,-48.68,;3.37,-47.78,;3.52,-46.25,;2.27,-45.35,;.81,-45.83,;-.1,-44.58,;.81,-43.34,;2.26,-43.81,;3.6,-43.04,;4.93,-43.81,;4.93,-45.35,;6.26,-43.04,;7.6,-43.81,;8.93,-43.04,;8.93,-41.5,;10.26,-43.81,;11.59,-43.04,;12.93,-43.81,;12.93,-45.36,;11.6,-46.13,;10.26,-45.36,;11.6,-47.67,;10.26,-48.44,;12.93,-48.44,;11.58,-49.2,;-1.64,-44.58,;-2.41,-45.92,;-3.95,-45.92,;-4.72,-44.58,;-5.13,-43.09,;-3.94,-43.25,;-2.41,-43.25,;-6.25,-44.58,;-7.02,-43.24,;-8.56,-43.24,;-9.33,-44.57,;-10.87,-44.57,;-8.56,-45.91,;-7.02,-45.91,)|
Structure
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