Reaction Details |
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Target | Prostaglandin D2 receptor |
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Ligand | BDBM50331730 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687945 (CHEMBL1291617) |
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Ki | 0.89±n/a nM |
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Citation | Li, L; Beaulieu, C; Carriere, MC; Denis, D; Greig, G; Guay, D; O'Neill, G; Zamboni, R; Wang, Z Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore. Bioorg Med Chem Lett20:7462-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin D2 receptor |
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Name: | Prostaglandin D2 receptor |
Synonyms: | PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor |
Type: | Enzyme |
Mol. Mass.: | 40288.87 |
Organism: | Homo sapiens (Human) |
Description: | Q13258 |
Residue: | 359 |
Sequence: | MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV
FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST
LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG
TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT
RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS
EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
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BDBM50331730 |
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n/a |
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Name | BDBM50331730 |
Synonyms: | (+/-)-2-(9-(4-chlorobenzyl)-6-fluoro-8-(methylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL1289984 |
Type | Small organic molecule |
Emp. Form. | C22H21ClFNO4S |
Mol. Mass. | 449.923 |
SMILES | CS(=O)(=O)c1cc(F)cc2c3CCCC(CC(O)=O)c3n(Cc3ccc(Cl)cc3)c12 |
Structure |
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