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TargetProstacyclin receptor
LigandBDBM50331737
Substrate/Competitorn/a
Meas. Tech.ChEMBL_686551 (CHEMBL1292338)
Ki 15510±n/a nM
Citation Li, LBeaulieu, CCarriere, MCDenis, DGreig, GGuay, DO'Neill, GZamboni, RWang, Z Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore. Bioorg Med Chem Lett20:7462-5 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostacyclin receptor
Name:Prostacyclin receptor
Synonyms:PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40968.22
Organism:Homo sapiens (Human)
Description:The membranes prepared from human platelet were used in binding assay.
Residue:386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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  Blast E-value cutoff:
BDBM50331737
n/a
NameBDBM50331737
Synonyms:2-((R)-6-fluoro-8-(methylsulfonyl)-9-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL1290413
TypeSmall organic molecule
Emp. Form.C24H23F4NO4S
Mol. Mass.497.502
SMILESC[C@@H](c1ccc(cc1)C(F)(F)F)n1c2[C@@H](CC(O)=O)CCCc2c2cc(F)cc(c12)S(C)(=O)=O |r|
Structure
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