| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin F |
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| Ligand | BDBM50331768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_686698 (CHEMBL1290878) |
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| IC50 | 56±n/a nM |
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| Citation |  Beaulieu, C; Isabel, E; Fortier, A; Massé, F; Mellon, C; Méthot, N; Ndao, M; Nicoll-Griffith, D; Lee, D; Park, H; Black, WC Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease. Bioorg Med Chem Lett20:7444-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin F |
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| Name: | Cathepsin F |
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| Synonyms: | CATF_HUMAN | CATSF | CTSF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53373.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_852650 |
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| Residue: | 484 |
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| Sequence: | MAPWLQLLSLLGLLPGAVAAPAQPRAASFQAWGPPSPELLAPTRFALEMFNRGRAAGTRA
VLGLVRGRVRRAGQGSLYSLEATLEEPPCNDPMVCRLPVSKKTLLCSFQVLDELGRHVLL
RKDCGPVDTKVPGAGEPKSAFTQGSAMISSLSQNHPDNRNETFSSVISLLNEDPLSQDLP
VKMASIFKNFVITYNRTYESKEEARWRLSVFVNNMVRAQKIQALDRGTAQYGVTKFSDLT
EEEFRTIYLNTLLRKEPGNKMKQAKSVGDLAPPEWDWRSKGAVTKVKDQGMCGSCWAFSV
TGNVEGQWFLNQGTLLSLSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQ
GHMQSCNFSAEKAKVYINDSVELSQNEQKLAAWLAKRGPISVAINAFGMQFYRHGISRPL
RPLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASS
AVVD
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| BDBM50331768 |
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| n/a |
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| Name | BDBM50331768 |
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| Synonyms: | (S)-N-((S)-1-cyano-2-(4-cyano-2-fluorophenyl)ethyl)-2-((S)-1-(4'-((R)-2,2-difluoro-1-hydroxyethyl)biphenyl-4-yl)-2,2,2-trifluoroethylamino)-3-methylbutanamide | CHEMBL1288532 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28F6N4O2 |
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| Mol. Mass. | 602.57 |
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| SMILES | CC(C)[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)[C@@H](O)C(F)F)C(F)(F)F)C(=O)N[C@@H](Cc1ccc(cc1F)C#N)C#N |r| |
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| Structure | 
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