Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 2 |
---|
Ligand | BDBM50332023 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_687566 (CHEMBL1290838) |
---|
Ki | >100000±n/a nM |
---|
Citation | Maresca, A; Scozzafava, A; Supuran, CT 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range. Bioorg Med Chem Lett20:7255-8 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 2 |
---|
Name: | Carbonic anhydrase 2 |
Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
Type: | Enzyme |
Mol. Mass.: | 29250.71 |
Organism: | Homo sapiens (Human) |
Description: | P00918 |
Residue: | 260 |
Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
BDBM50332023 |
---|
n/a |
---|
Name | BDBM50332023 |
Synonyms: | 6-Acetyl-7-(2-adamantan-1-yl-ethoxy)-chromen-2-one | CHEMBL1290110 |
Type | Small organic molecule |
Emp. Form. | C23H26O4 |
Mol. Mass. | 366.4501 |
SMILES | CC(=O)c1cc2ccc(=O)oc2cc1OCCC12CC3CC(CC(C3)C1)C2 |TLB:26:17:24:21.20.22,THB:26:21:17.18.25:24,22:21:18:25.23.24,22:23:18:26.21.20,16:17:24:21.20.22| |
Structure |
|