Reaction Details |
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Target | Mitogen-activated protein kinase 8 |
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Ligand | BDBM50332075 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_687739 (CHEMBL1291185) |
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IC50 | 3400±n/a nM |
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Citation | Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Tóth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorg Med Chem Lett20:7303-7 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 8 |
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Name: | Mitogen-activated protein kinase 8 |
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
Type: | Enzyme |
Mol. Mass.: | 48297.57 |
Organism: | Homo sapiens (Human) |
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
Residue: | 427 |
Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
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BDBM50332075 |
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n/a |
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Name | BDBM50332075 |
Synonyms: | CHEMBL1288004 | N-(2-(5-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide | US9796706, Compound 74 |
Type | Small organic molecule |
Emp. Form. | C20H17N3OS |
Mol. Mass. | 347.433 |
SMILES | Cc1cc(n[nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12 |
Structure |
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